The aim of present research is to extract the stem bark of Terminalia superba stem bark using alcohol and to evaluate anti-ulcer and antimalarial activity respectively. Ethanolic extract of Terminalia superba stem bark was evaluated invitro antiulcer activity by indomethacin induced ulcer model and anti-malarial activity by Schizonticidal testing method Assay. In this model, Indomethacin an (NSAID) drug induced ulcer model, the animals given with indomethacin (50 mg/kg) a caused damage to the gastric mucosa. Animals pretreated with ethanolic extract of Terminalia superba of 100 and 200 mg/kg and standard drug ranitidine (50 mg/kg) has significantly protected gastric lesions induced by indomethacin. In this research work, firstly, ethanolic extract Terminalia superba were subjected to the susceptibility assay for Plasmodium falciparum to find out whether the synthesized derivatives possess anti-malarial activity or not. The results revealed that alcoholic extract Terminalia superba shown good activity when compared to standard. Conclusions: The research work involves screening of ethanolic extract of Terminalia superba stem bark for antiulcer activity by indomethacin induced ulcer model using ranitidine as a standard. From the results it is concluded that the extract shown promising anti-ulcer actitivity when compared to standard ranitidine. The ethanolic extract were also screened for antimalarial activity using plasmodium falciparum susceptibility assay model using chloroquine phosphate as a standard from the results it is concluded that the extract shown potent activity when compared to standard Chloroquine.