Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
The present investigation aimed to evaluate the anticonvulsant effect of Allyl isothiocyanate (AITC) on chemically induced convulsions in experimental animals and compare the effect of AITC with the standard dose of Diazepam on Pentylenetetrazol (PTZ) and Strychnine-induced epilepsy model. Moreover, brain GABA levels were estimated to investigate the mechanisms underlying the anticonvulsant activity. In this study, AITC (5, 10, and 20 mg/kg, p.o.) showed significant and dose-dependent inhibition of PTZ and Strychnine-induced convulsions. Furthermore, administration of AITC showed significantly increased GABA levels in the brain. The parameters observed in PTZ and Strychnine-induced models were seizure latency, duration, and mortality. AITC showed significant anticonvulsant activity.