Epilepsy disease continues to be a neurological disease, and safer drugs with improved anticonvulsant efficacy are awaited. The purpose: In the present study, the ethanolic extract of Senna singueana root was investigated for protective effects against maximal electric shock (MES) and strychnine (STN)-induced seizures in rats. Method: Anti-convulsant animal models included maximal electric shock (MES) and strychnine (STN). Each animal model (MES, STN) comprised four groups of albino rats (n=6). First is control, second standard, third and fourth tested MES generated seizures with a 60 Hz alternating current at 150 mA for 0.2 s. In the third and fourth groups, rats were pre-treated with an ethanolic extract of Senna singueana root (EESS) 200 and 400 mg/kg/p.o. for 14 days, while the standard group was pre-treated with phenytoin (25 mg/kg/i.p.). For strychnine-induced convulsions, animals in the third and fourth groups were pre-treated with EESS 200 and 400 (mg/kg/p.o) for 14 days, whereas those in the standard group received diazepam (4 mg/kg/ip). Strychnine (2.5 mg/kg/i.p.) caused convulsions on day 14.