Effect of Antihyperlipidemic and Phytochemical Screening of Vitex Trifolia Linn and Corchorus Trilocularis In Rat Material & Method: Fresh leaves (immature, mature and senescence) were collected, air dried and the crude powder was prepared for phytochemical and antioxidant analysis. The powder was mixed with 70% methanol and the supernatant was separated. The antioxidant activity of this ethanolic extract was measured on the basis of the scavenging activity 1, 1-diphenyl 2-picrylhydrazyl (DPPH) free radical with slight modifications. Phytochemical analysis was performed according to standard laboratory protocol. Screening of antihyperlipidemic was done by using Corchorus trilocularis and Vitex trifolia linn. Leaves part extracts used for antihyperlipidemic activity leaves (200mg/kg and 400mg/kg). Hyperlipidemia was administered in experimental animals using high fat diet. In order to collect blood for high fat diet-induced hemolysis, heart punctures were performed after 14 days hyperlipidemia. Antihyperlipidemic activity of Corchorus trilocularis and Vitex trifolia linn plant extracts were evaluated by estimation of lipid profiles and standard drug Atorvastatin for 14 days.