High blood glucose levels are a prominent feature of the severe chronic degenerative disease known as diabetes mellitus (DM). It is connected to a complete or partial lack of insulin synthesis and/or action. Coronary illness, retinopathy, renal sickness, and neuropathy are a couple of the issues connected to DM; subsequently, new all-regular therapies are being tried to deal with the condition. In this review, we survey the anti-diabetic activity of Spondias purpurea seed methanol remove (CSM) both in vitro and in a zebra fish model of diabetes that has been produced by glucose. This study's goal was to decide the effect of a methanol concentrate of Syzygium cumini (L.) Skeels. Seed on risky microorganisms and diabetes welcomed on by a solitary intraperitoneal infusion of streptozotocin in rodents. S. cumin, a plant used to treat type 2diabetes I frequently used seeds in powered form. Pathogenic bacterial resistance was examined in S. cumin seed methanol extract. When tested against Bacillus subtilis, E. coli, Staphylococcus aureus, and Klebsiella pneumonia, the anti-bacterial activity performed well. Analysis using TLC and HPLC demonstrates the presence of 11 different chemicals. Rat experiments demonstrated that seeds have positive effects on diabetes mellitus.