Purpose: The purpose of the study was to evaluate and compare the bond strength of the Conventional Cast Metal and CAD/CAM Zirconia posts with different luting agents. Materials and Method: Post spaces were prepared in sixty extracted maxillary anterior teeth and divided into two main groups of 30 teeth each for cast metal (M group) and CAD/CAM zirconia posts (Z group).These groups were further divided into 6 subgroups of ten specimen each (n=10) according to the cement used for post cementation as follows: M1,M2 & M3 for Cast metal posts and Z1,Z2 & Z3 for CAD/CAM Zirconia posts luted with Resin modified GIC (GC Fuji Cem 2), 10 MDP based Self adhesive Self cure resin cement (Speed CEM Plus) and 10 MDP based Self adhesive Dual cure resin cement (Multilink N) with silane coupling agent respectively. The specimens were subjected to a pull out bond strength test in a Universal testing machine at a cross head speed of 0.5mm/min. Data was analyzed using analysis of variance (ANOVA) and Post Hoc Test (Bonferroni)