The aim of this study is to evaluate the efficacy of turmix in the treatment of oral submucous fibrosis patients. Objectives: To check the treatment efficacy of turmix in the terms of burning sensation on visual analog scale, and to check the treatment efficacy of turmix in the terms of mouth opening on a calibrated scale. Materials and methods: 30 patients diagnosed with Oral Submucous Fibrosis (OSMF) were included in this study. The patients were administered commercially available turmix tablets, their mouth opening and burning sensation on Visual Analogue Scale (VAS) scale were evaluated at regular intervals, and the data was then compared. Results: The improvement in mouth opening was not significant, however the change in burning sensation on VAS was significant. Conclusion: It is evident from the study that turmeric holds good promise in the treatment of OSMF in future.