Object: This research is to evaluate the generic Regional Health Information System (SIKDA) with the Delone and Maclean Information System Success Model Approach at the Health Office in Ambon City. Method: Using analytic observational method as a research design. The population and sample are the same because they use a total sampling technique which involves 118 respondents, namely employees from 3 Community Health Centers in Ambon city who have applied Generic SIKDA for 1 year. Data obtained by distributing questionnaires and measured by analysis using Structural Equation Modeling (SEM) will be processed using AMOS software version 24.00 Results: System quality has an effect on Generic SIKDA user satisfaction and User satisfaction has a significant effect on net benefits. Conclusion: Information quality and quality have no significant effect on user satisfaction, system quality has an effect on Generic SIKDA user satisfaction and user satisfaction has a significant effect on net benefits.