This paper presents a comparative analysis of global healthcare systems, focusing on key indicators and guidelines aimed at enhancing sustainability and efficiency. The study utilizes a systematic review of existing literature, incorporating data from reputable sources such as the World Health Organization (WHO) and academic publications. By examining various aspects including access, quality, cost-effectiveness, and innovative strategies, this paper aims to provide insights into the strengths and weaknesses of different healthcare systems worldwide. Additionally, it offers recommendations for policymakers and healthcare practitioners to improve the sustainability and efficiency of healthcare delivery.