Oxidative stress is the major role involved in the etiology of depression. Reduced oxidative stress correlates with the antidepressant treatment and brings the moderate clinical recovery of depression. Natural antioxidants that are present in herbs and spices are responsible for inhibiting and preventing the deleterious consequences of oxidative stress. Different concentrations of Jasminum sambac were used to evaluate the antioxidant effect. The in-vivo antioxidant was evaluated by MDA, serum catalase, superoxide dismutase and reduced glutathione reactive substance assay method. The in-vivo antiparkinson activity of methanolic extract of Jasminum sambac flower were evaluated by using Locomotor and Rotarod method. Male albino rats were treated at a dose of 200 and 500mg/kg I.P and behavior was observed on these models.