Background: The general Public compliance with preventive measures and legislation is mainly influenced by their knowledge level, attitude, and practices. This study evaluation the knowledge, attitude, and practices of public residents towards corona virus disease preventive measures in Makkah Al-Mukarramah Saudi Arabia 2022. On December 31, 2019, the World Health Organization (WHO) Regional Office in Wuhan City, Hubei Province, China, reported cases of pneumonia of an unknown cause. Most patients worked at or lived around the local Huanan seafood wholesale market, where live animals were also on sale. The symptoms ranged from those of a common cold to those of more severe diseases, such as Middle East respiratory syndrome (MERS-CoV) and severe acute respiratory syndrome (SARS-CoV), which are examples of a large family of viruses called coronaviruses (CoV). Aim of the study: To Evaluation of Knowledge, Attitude and Practice during the COVID-19 pandemic among the Public in primary health care center in Makkah Al-Mukarramah Saudi Arabia 2022. Method: Cross sectional study, was conducted among Saudi Arabia Public in primary health care center in Makkah. The questionnaire collected socio-demographic characteristics, assessment of Knowledge, Attitude and Practice toward COVID-19 Our total participants were (300). Results: shows regarding the age majority of the study groups were in the age range of (25 - 50%) years were (41.0%) the gender many of the respondents were male (58.0 %) education status, the majority of the respondents had Postgraduate degree were (49.0%) while Occupation the most of the participants Students were (32.0%) the income The majority of them had an income from More than 5000SR-10000 were (40.0%) Conclusion: This study showed satisfactory knowledge, attitude, and practice towards corona virus disease-2019 in Saudi Arabia. The educational level is a dominant influencing factor for knowledge, attitude, and practice and three studies indicated that respondents have not good practices and followed such practices related to COVID-19. Good KAP is a tool that can hopefully be used to control the spread of COVID-19, in our Study participants not adequate knowledge, positive attitude, and acceptable practices towards COVID-19 Knowledge.