Oral drug delivery is considered to be the most suitable drug delivery system (DDS) for the systemic circulation. Oral drug release system gained interest in the field of pharmaceuticals because of various advantages, i.e. proper therapeutic response, easy in dose administration, patient compliance etc. After oral delivery of a drug, the drug should be retained in the stomach and release the drug in a well-ordered way, so that the delivery of drug is continuous at its absorption sites in GIT (gastro intestinal tract). Floating drug delivery systems (FDDS) or hydro dynamically balanced systems have a bulk density lower than gastric fluids and thus remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. While the system is floating on the gastric matters, the drug is released gradually at a desired rate from the stomach. After the release of the drug, the residual system is emptied from the stomach. The aim of the present research work was to formulate and evaluates the floating floating tablet of glibenclamide. The floating tablet of highly water soluble anti-diabetic drug, glibenclamide (GL) was prepared using Magnifera indica gum as the polymer by employing solvent evaporation method.