Introduction: Glucose is the brain's primary source of energy. Decreased brain energy metabolism is linked to cognitive dysfunction in depressive disorders. Lactate has long been thought to be a glycolytic by-product in the brain but lactate has been transposted to the brain by monocarboxylate transporters (MCT). Aim: To determine the effect of depression on monocarboxylate transporter (MCT) expression in the rat brain. Methods: Depression was induced in wistar rats by a CUMS (Chronic Unpredictable Mild Stress) Protocols. Rats were scarified after 30days, and the brain levels of MCT2 and MCT4 were assessed with semi-quantitative RT-PCR and Western blotting analysis. Results: Gene expressions of mct2 and mct4 were analyzed using semi-quantitative RT-PCR that showed significant decrease in mct2 and mct4 during chronic stress and their respective increase on administration of plant extracts and exercise treatment. MCT4 protein expression were significantly found to be decreased in Group II and increased in plant and swimming exercise treated groups when compared to normal. Conclusions:The expression of brain MCT2 and MCT4 is significantly increased after treatment with Sesbania bispinosa and swimming exercised rats.