Background: Taste sensation is one the most important factor which not only affects but also regulates the choice of acceptance or nonacceptance of food. Very limited research works are there based on the alteration of taste sensation in patients with Oral submucous fibrosis (OSMF). The aim of the study is to assess and compare taste perception among Oral submucous fibrosis patients and healthy controls. Material and methods: This study was conducted to analyze the taste impairment in OSMF patients by using four basic tastes: Sweet, sour, salty, and bitter, with a sample size of 60 subjects (30 patients with OSMF comprising the study group and 30 healthy controls) by making use of physiological taste stimuli tastants