The purpose of this study was to evaluate nurses' practices related to injection safety in a healthcare setting. Injection safety is critical to preventing infection and ensuring patient safety. Assessing nurses' compliance with injection safety practices can help identify gaps and initiate improvements. The study used a cross-sectional design and collected data through questionnaires and direct observation. The sample consisted of nurses working in different clinical areas of the healthcare facility. Data analysis included descriptive statistics and correlation analysis. Results identified strengths and weaknesses of nursing practices related to injection safety. Recommendations are made to improve compliance with injection safety practices, including targeted education, improving the availability of supplies, and creating a culture of safety within the organization. This study highlights the importance of ongoing assessment and continuous improvement of nurse injection safety practices.