Aim: To evaluate and compare the efficacy of platelet-rich plasma (PRP) and a blood clot for regenerative treatment in non-vital teeth. Objective: Regenerative endodontic procedures (REPs) aim to regenerate replacement pulp to strengthen the tooth structure. So, the study aimed to observe the efficacy of platelet-rich plasma and a blood clot as scaffolds for regenerative treatment in non-vital teeth with periapical pathology