For a long time, haematological tests have been thought of as potential diagnostic and prognostic indicators in the development of Chronic Periodontitis. The relatively new markers Neutrophil to Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR), which are obtained from peripheral blood counts, may be used in conjunction with an exaggerated understanding of these markers to serve as a potential marker in the understanding of the relationship between Chronic Gingivitis, Chronic Periodontitis and Systemic Inflammatory response. There hasn't been much research done on these indicators in relation to Gingivitis and Periodontitis. Materials and Methods: 75 Patients were enrolled and 90 samples were collected. Group I-Controls (25 Patients) who were assessed at baseline and Post-treatment after 4 weeks, Group II-Chronic Gingivitis (25 Patients) and Group III Chronic Periodontitis (25 Patients). GI, PI, PPD, CAL, Neutrophil Count, Lymphocyte Count and Platelet counts were obtained and assessed at baseline and Post-treatment after 4 weeks. The ratio of neutrophils to lymphocytes, or NLR, and the ratio of platelets to lymphocytes, or PLR, were calculated. Results: The results varied significantly between Group A and Group C at baseline and post-treatment , however the results were insignificant between Group A and Group B at baseline and post-treatment. The ROC cut off values for NLR and PLR was found to be 1.843 and 99.5 respectively which may be used as prognostic values for Chronic Periodontitis. Conclusion: In order to bridge the link between periodontal and systemic diseases, NLR and PLR may be used as possible biomarkers of the SIR to CP.