Acute Coronary Syndrome (ACS) refers to a spectrum of clinical presentation ranging from those for ST segment elevation Myocardial Infarction (STEMI) to presentations found in non- ST- segment elevation Myocardial Infarction (NSTEMI) or in unstable angina. Among this NSTEMI represents the major burden to health care systems and patients face a substantial risk of mortality and cardiovascular events. Educational interventions can be effectively targeted and implemented as primary and secondary prevention strategies to reduce the burden of coronary atherosclerotic heart disease. OBJECTIVES: Evaluate the effectiveness of preparatory informatics on biophysiological parameters among the patients with ACS. Determine the effectiveness of preparatory informatics on compliance to lifestyle modifications among the patients with Acute Coronary Syndrome. DESIGN: A quantitative method, true experimental research design. SETTING: Cardiac Super specialty Hospital, Chennai, India. MAIN OUTCOME MEASURES: Change in the BMI, lipid profile, regulate blood pressure and develop good compliance behavior towards lifestyle modifications SAMPLE SIZE: 200 participants were selected by using power analysis. By simple random sampling technique,100 each in study and comparison group. RESULTS: The comparison scores of biophysiological parameters such as BMI, SBP, DBP, TC, LDL and HDL between the study and comparison group was statistically significant at p <.001 except for DBP which was significant at P<.01.The comparison scores of compliance to lifestyle modifications between the study and comparison group were statistically significant at P<.001. LIMITATION: The biophysiological assessment were carried out twice only due to hospital protocol. CONCLUSION: These comprehensive interventions on lifestyle modifications, printed hand outs and telephonic reinforcement are accomplished in increasing the compliance behavior among patients with acute coronary syndrome.