Background Obesity is a major international disaster health problem that leads to increasing the risk of several chronic complications occurrence. The present study aiming to Evaluation of prevalence of obesity-related risk factors among adolescent students at Makkah in Saudi Arabia 2022. The prevalence of obesity is increasing rapidly worldwide.1 This may leads to of heart disease and other chronic diseases including hyperlipidemia, hyper-insulinaemia, hypertension, and early atherosclerosis. The adolescent students, including secondary school students are in a high risk side when obesity is concerned. This is mainly because of the modernization and industrialization which has led to sedentary life style and unhealthy eating pattern. The issue of being overweight and obese is becoming an increasingly prevalent problem in both the developed and developing world, and it is one of the most serious public health challenges of the 21st century. The study aimed: To evaluation of prevalence of obesity-related risk factors among adolescent students at Makkah in Saudi Arabia 2022. Method: Cross-sectional survey was utilized adolescent students in Makkah Al-Mukarramah in Saudi Arabia 2022 during the November to December, 2022, a total of 200 student aged 12–18 years, available adolescent students. A structured self-reported questionnaire sheet was used To evaluation of prevalence of obesity-related risk factors among adolescent students at Makkah in Saudi Arabia 2022 Result: show the total number of participants was 200 more than half of the participants (69.0%) answer No practice Physical activities or exercise physical, regarding If yes What is type of physical activities or exercises the majority of the participants running were (48.72%), regarding you stop aerobic exercise for two consecutive days or more per week the majority of the participants always were (71.79%). Regarding Risk factor the majority of the participant's High blood pressure were (31.0%). Conclusion: The measurement of obesity using guideline shows a definite increase in prevalence of obesity among adolescent students. Reinforcing the need to encourage healthy lifestyle, healthy food habits and a physically active daily routine, among the adolescents, including secondary school need to be focused to prevent this obesity related disease epidemic.