To evaluate the salivary and serum stathmin levels in patients with leukoplakia and Oral squamous cell carcinoma and to histopathologically correlate with different grades of dysplasia in patients with leukoplakia and Oral squamous cell carcinoma. Materials and methods: Three groups were analysed for stathmin levels using ELISA kit.GROUP A-Healthy controls(n=15) ,GROUP B-Leukoplakia patients (n=15) ,GROUP C-15 oral squamous cell carcinoma patients(n=15) saliva and serum samples collected from each group. Incised tissue samples of all three groups were processed and assessed for histopathological grades of oral epithelial dysplasia and grades of oral squamous cell carcinoma Results: The mean salivary and serum stathmin levels among three groups was statistically significant. There was a moderate positive correlation between the mean serum and mean salivary stathmin levels among the leukoplakia and oral squamous cell carcinoma. The correlation of salivary and stathmin levels in leukoplakia and oral squamous cell carcinoma with grades of oral epithelial dysplasia and grades of oral squamous cell carcinoma were found not to be statistically significant. Conclusion: It was speculated that the salivary and serum stathmin assessment could be a potent biomarker in the early diagnosis of the oral leukoplakia and oral squamous cell carcinoma. Clinical significance: Salivary stathmin levels can be used for the assessment of diagnostic and prognostic parameters of oral leukoplakia and Oral squamous cell carcinoma in their early diagnosis and better prognosis. This could be used as a prognostic marker in the high-grade cases of dysplasia and oral squamous cell carcinoma.