Introduction: The study aims to evaluate the role of the triglyceride-glucose index in determining glycemic control in patients with type 2 diabetes mellitus in a tertiary care center in Murshidabad. There are other studies that have shown the utility of triglyceride-glucose index for glycemic monitoring purposes but evaluation of this marker in glycemic control has not been done in the population in eastern part of India especially in Murshidabad. Objective: To evaluate TyG index as a marker of glycemic control in the patients of type 2 diabetes mellitus of Murshidabad District situated at eastern part of India. Methodology: The study consists of 120 type 2 diabetes mellitus patients, and biochemical parameters such as fasting blood glucose, triglyceride and HbA1c were analyzed using standard biochemical methods. Type 2 diabetes mellitus patients, were categorized into two groups according to their HbA1c value: good control (≤7.0) and poor control (>7.0) based on previous study. After analysis of biochemical parameters, statistical analysis done in Statistical Software for Social Sciences software (SPSS) version 20.