Dapsone is used to treat leprosy and associated disorders because it is said to be active against the Mycobacterium leprae. The goal of this study was to create mouth-dispersing Dapsone tablets using the direct compression method and excipients such as sodium starch glycolate (SSG), crospovidone (CP), croscarmellose sodium (CCS), and others that are directly compressible. The hardness, friability, weight variation, in vitro dispersion time, wetting time, water absorption ratio, drug content uniformity, and in vitro dissolve rate of the developed oral mouth dissolving of Dapsone were all assessed. Based on the findings of an in vitro drug release research done in 0.1N HCL (PH 1.2), F- 6 was chosen as the formulation that was optimized among all the others, and the in vitro release profiles were 99% accurate.