The aim of the present study was to evaluate the potency ofethanolic extract of Cassia fistula against fructose induced Non-alcoholic fatty liver disease in experimental rats. NAFLD is defined as accumulation of fat, triglycerides in hepatocytes. Cassia fistula belongs to the family leguminosae. The experimental animals were randomly divided in to 5 groups (n= 6) normal, control, standard, test-1and tet-2 groups and treated for 5 weeks as per the treatment schedule. NAFLD was induced by drinking water containing 10% fructose for 5 weeks. EECF was administered to animals for 5 weeks by oral feeding needle. Studies have shown that there was significant (p<0.001) increase in serum parameter levels in control group when compared with normal group. The groups (G-V) receiving EECF (400 mg/kg) showed a significant (p<0.001), decrease in serum levels, whereas group (G-IV) receiving EECF (200 mg/kg) also showed significance in decreasing the serum levels when compared to control group (G-II). Hence it is concluded that EECF provides protection against fructose induced NAFLD in male wistar albino rats. Hence, orally applicable, EECF may have great potential as an alternative to the therapeutic agents currently available for treatment of NAFLD.