The present study, designed to investigate the role of huperzine and resveratrol in stress andintracerebroventricular injection of streptozotocin (i.c.v. STZ) induced changes of cognitivefunction in rat. The cognitive impairment was induced by the application of chronic swimmingstress i.e., 15 minutes / day, for 25 consecutive days. The pre-treatment of huperzine (20 and 40mg/kg); resveratrol (20 and 40 mg/kg); thalidomide (25) and piracetam (300 mg/kg) wereadministered by oral gavage (p.o.) method for 10 consecutive days from day of 15th to 25th day.The changes of stress and i.c.v. STZ induced cognitive dysfunction were assessed by Morriswater maze (MWM) test from the day of 21st to 25th day. Furthermore, the stress and i.c.v. STZinduced biochemical changes i.e., acetylcholinesterase activity