Objective: This study seeks to comprehensively examine the role of the intestinal microbiota in the progression of Parkinson's disease through a thorough literature review. Background: Parkinson's disease is characterized by the degeneration of dopaminergic neurons in the substantia nigra (pars compacta). The disease's incidence varies with age and gender, predominantly affecting men over the age of 60. Despite its prevalence, the primary cause of neuronal death in Parkinson's remains elusive, with potential contributors including mitochondrial dysfunction, α-synuclein aggregation, impaired autophagy, endoplasmic reticulum (ER) stress, deregulation of cell homeostasis, and intracellular calcium. Microbiota's Impact on Parkinson's Disease: Evidence suggests that compounds produced by the gut mi6crobiota may possess anti-inflammatory and antioxidant properties, potentially offering therapeutic benefits in Parkinson's disease. Moreover, a correlation has been established between the gut microbiota and the production of dopamine, a crucial neurotransmitter significantly reduced in individuals with Parkinson's. Conclusion: This structured review underscores the significance of the microbiota-gut-brain axis in the context of Parkinson's disease. Understanding the interplay between the intestinal microbiota and the pathological processes associated with Parkinson's may open avenues for novel therapeutic interventions targeting the gut to mitigate the progression of this neurodegenerative disorder..