There are numerous technological and industrial uses for hybrid nanofluids formed by suspending two or more different types of nanoparticles in the base fluid. The current study looks at the different thermo-physical and heat transfer properties of hybrid nanofluids that could be used as industrial coolants or heat transfer fluids. The hybrid nanofluid (hybrid nano-diesel) is composed of diesel as the base fluid and hybrid nanoparticles consisting of copper-alumina oxide (CuO-Al2O3), graphene-alumina oxide (Gr-Al2O3), and copper-graphene oxide (CuO-Gr) for this analysis. The major purpose of developing hybrid nanofluids is to improve the characteristics of mono nanofluid by significantly improving their thermal or rheological properties over ordinary nanofluids or nanolubricants. According to the results, CuO-Gr hybrid nano-diesel increases thermal conductivity by 29.5% and reduces specific heat by 5% at mass fractions of 2%. However, as more mass of nanoparticles is added, the hybrid nano-diesel's viscosity increases; however, the effect of surfactant addition with increasing mass fraction causes the viscosity to fall by 17.5% at the same mass fraction of 2%. The same sample's surface tension also lessens by 10%. According to the experimental findings, CuO-Gr hybrid nano-diesel performs extremely well across the board in thermal analysis. The Nussult number of CuO-Gr hybrid nano-diesel increases by 11%, as do the heat transfer properties. At 2% mass fraction, the heat transfer coefficient increased by the most, at roughly 18% corresponding to Reynolds number of 5474, showing that the matching sample is the best suited for heat transfer applications out of all samples. The Prandtl number of the sample reduces by 5.5% for a mass fraction of 2%.