Nerium oleander and Thevetia neriifolia are lethal plants. Poisoning by them is common in tropical and subtropical regions. All parts of these plants are toxic, containing cardiac glycosides. Ingestion causes nausea, vomiting, abdominal pain, diarrhoea, dysrhythmias, and hyperkalemia. Treatment involves activated charcoal and supportive care. Digoxin specific Fab fragments are effective but may be restricted by limited economic resources. Materials and methods: Terminalia chebula was evaluated against Thevetia neriifolia as antidote in Swiss albino mice. Fructose 1, 6 Diphosphate was used as standard antidote.Assessesment was done in terms of physical signs, ECG changes. Results: Terminalia Chebula significantly increases Time of appearance of tremors (P= 0.024); Time of appearance of RSR (P<0.05); Highly significant in increasing the time of appearance of Paralysis P<0.01); the time of appearance of IRDR (P<0.05); the time of appearance of convulsions (P<0.05); the time of appearance of LORR (P<0.05); the duration of survival period (P<0.05) as compared to control group when administered as antidote against Seed of Thevetia Neriifolia. It also significantly increases time of appearance of tremors (P= 0.0143); time of appearance of RSR (P= 0.0196); time duration of appearance of Paralysis (P= 0.0429); significantly increases the time duration of appearance of IRDR RK (P= 0.0196); time of appearance of convulsions (P=0.0196); duration of survival period (P= 0.0455); But not found significantly effective to increase the time of appearance of LORR (P= 0.0619) when administered as antidote against root of Thevetia Neriifolia. Conclusion: So, This study proposes Terminalia chebula for further clinical evaluation of its Antidote properties against Thevetia neriifolia