The development of gastroretentive drug delivery systems has raised the possibility of improving the bioavailability and effectiveness of a variety of medicinal substances. The benefits and drawbacks of using gastroretentive systems for medication delivery are carefully assessed in this research. The principal aim is to conduct a thorough analysis of their mechanisms, formulation methodologies, and prospective uses. Particular attention will be paid to their capacity to extend the stomach residence time and enhance medication absorption. Gastroretentive drug delivery systems have the advantage of slowing down drug release, preserving therapeutic concentrations, and requiring fewer doses. For medications that target particular parts of the gastrointestinal tract or have a limited window of absorption, this prolonged gastric residence duration offers a practical strategy. These technologies may also enhance patient compliance, which would enhance the effectiveness of treatment. The review does, however, also point out a number of difficulties with gastroretentive devices. Significant restrictions include the possibility of gastrointestinal side effects, danger of local irritation, variability in stomach emptying, and intricate formulation and manufacturing procedures. Furthermore, cautious thought must be given to regulatory issues as well as the possible risk of device dislodgement or aspiration.The present knowledge of gastroretentive drug delivery systems is consolidated in this review, which also highlights the need for more study to overcome these shortcomings. To maximize the safety, effectiveness, and practicality of these systems in clinical practice, it will be necessary to make further strides in formulation processes, creative design approaches, and an improved understanding of patient variability.