Candidiasis a pathologically important condition imposing huge impact on mankind as it is mainly found in the immunocompromised patients. Emergence of resistance against existing antifungals makes them ineffective causing high incidence and accompanying mortality due to fungal infections. Generation of biofilms by various species of candida is the most frequent underlying mechanism in the emergence of resistance. Development of newer antifungal with lower resistance remains a challenging task for the researchers. In this report, we have developed a facile and environment friendly synthesis of quinazoline-indazole scaffold and investigated their anti-biofilm, antifungal potential. Among the synthesized compounds, 14i and 14m have shown potent inhibitory activity against C. albicans than Fluconazole (standard antifungal agent). Compound 14j 14k and 14n also exhibited significant antibiofilm and antifungal activity as compared to fluconazole against C. albicans. The above results could serve as important lead in the discovery of effective antifungal agent to overcome the resistance problem associated with the existing antifungal agents.