In the present investigation, the hot melt coating technique has been assessed for its taste masking potential of tenofovir. Drug was fabricated into pellets by extrusion and spheronization method and coated with using Gelucire 43/01 and Precirol. The prepared pellets were evaluated for flowability, physicochemical properties and taste masking ability. Taste masking ability of technique was characterized by spectrophotometric and taste panel methods. The coated pellets were with good to excellent flowing ability and acceptable physicochemical properties. The threshold bitterness of drug was found to be 250 µg/ml. All the coated pellet formulations mask the bitter taste for minimum first 1-1.5 min indicating completely masking of the drug taste. Taste masking evaluation of pellets indicates that 80% volunteer reported slight bitter taste at 2% w/w level of hot melt coating agent and 3 & 5% w/w coating levels were qualified to mask the bitter taste. Both Precirol and Gelucire 43/01 shows excellent taste masking potential for masking taste of tenofovir.