Aim: This comprehensive review aims to explore and establish a clear understanding of the link between allergies and chronic otitis media. By analyzing existing literature and research, the study seeks to uncover the potential connections, mechanisms, and implications of allergies in the development and exacerbation of chronic otitis media. Background: Chronic otitis media is a prevalent condition characterized by long-standing inflammation of the middle ear. Allergic reactions have been proposed as a contributing factor in the pathogenesis of chronic otitis media. However, the precise nature of the relationship between allergies and chronic otitis media remains to be fully elucidated. This review delves into the existing knowledge surrounding both allergies and chronic otitis media to provide a comprehensive background for the exploration of their potential link. Methods: A systematic review of relevant literature was conducted to gather and synthesize available information. Databases were searched for studies investigating the association between allergies and chronic otitis media, considering both clinical and experimental research. The methodology involved selecting studies based on predefined criteria, extracting key findings, and analyzing data to identify common trends and correlations. Results: The review presents a synthesis of findings from multiple studies that collectively suggest a complex interplay between allergies and chronic otitis media. The results highlight various mechanisms through which allergies might influence the development and persistence of chronic otitis media, including immune responses, inflammation, and mucosal dysfunction. Additionally, the review discusses the potential impact of allergic factors on treatment outcomes and recurrence rates. Conclusion: This comprehensive review underscores the significance of recognizing the potential link between allergies and chronic otitis media. While the exact causal relationship remains inconclusive, the evidence suggests a plausible association that warrants further investigation. Understanding the mechanisms underlying this connection could open avenues for more targeted and effective therapeutic interventions for chronic otitis media patients with underlying allergic conditions.