Spathodea campanulata commonly known as the African tulip tree belongs to the family Bignoneaceae. The leaves of this tree were found to be rich source of various secondary metabolites and have been used in several ailments in traditional systems of medicine. Hence this study aims to assess the anti-Parkinson efficacy of Spathodea campanulata phytoconstituents in leaf extract by in-silico and in-vivo experiments. Molecular docking score and ADMET properties of the phytoconstituents of Spathodea campanulata were predicted using schrödinger software. The effect of Spathodea campanulata was evaluated in haloperidol induced parkinson’s rats, the evaluation of in vivo anti-Parkinson’s effect was performed by behavioural studies that include catalepsy and rota rod test and biochemical assays like estimation of catalase, acetylcholinesterase and dopamine. In-silico studies revealed that cerebroside, catapol and specioside had the highest docking scores among all the other selected phytochemicals with protein targets of PD. In-vivo study results showed significant decrease in cataleptic scores, significant increase in fall-off time in rota rod test and biochemical estimations revealed significant increase in the catalase enzyme activity and dopamine levels, whereas significant decrease in acetylcholinesterase enzyme activity in the brain when treated with leaf extract of Spathodea campanulata. Therefore, in conclusion study revealed the significant activity of Spathodea campanulata leaf extract against Parkinson’s disease. Further, the results suggest that Spathodea campanulata has a promising therapeutic potential against Parkinson’s disease and further research can explore its molecular mechanism and disease- modulating pathways.