Diarrheal diseases remain a significant global health concern, particularly in regions with limited access to healthcare and safe drinking water. The search for effective, affordable, and sustainable treatments for diarrhea continues to be a priority in the field of medical research. Capparis zeylanica, a plant widely distributed in tropical and subtropical regions, has been traditionally used for its medicinal properties. This study investigates the Antidiarrheal potential of Capparis zeylanica leaf extracts, aiming to provide scientific validation for its traditional use. The present study investigated the potential antidiarrheal effects of methanolic leaf extract derived from Capparis zeylanica (Capparidaceae) using a castor oil-induced diarrhea model and the small intestine transit method in mice. In comparison to loperamide (2 mg/kg/bw), the ethanolic extract of C. zeylanica (administered at doses of 100, 200, and 400 mg/kg body weight) demonstrated a noteworthy reduction in the severity of diarrhea. The level of protection observed in animals treated with the extract and experiencing diarrhea was compared to those treated with castor oil and loperamide. Notably, the antidiarrheal activity exhibited a dose-dependent response. Additionally, when assessed for its impact on intestinal transit, the extract displayed a substantial decrease in intestinal motility. These results indicate that the ethanolic extract effectively mitigated diarrhea in mice, accompanied by a reduction in stool weight. Further investigation into safety profile of these extracts is warranted to support their development as a viable therapeutic option for diarrheal diseases