Myocardial infarction and congestive heart failure symptoms seem to occur more commonly at night or in the early morning. These episodes are typically brought on by high blood pressure, especially immediately after waking up. There are many standard dose forms available to treat hypertension. The antihypertensive medications are currently administered in instant release dose forms. Because they don't provide the best doses at the critical moments, conventional medication delivery systems are ineffective for the effective control of hypertension. The term "chronotherapy" refers to the synchronization of biological rhythms with medical treatment. There are various methods for creating pulsatile drug delivery systems that are chrono regulated, and these methods have been evolved to closely resemble new chronotherapeutic concepts. These issues with conventional dose forms and controlled release dosage forms are resolved by the chorono modulated captopril drug delivery system. In order to effectively manage hypertension, a chorono regulated captopril drug delivery system that releases the medication at the site of absorption at a predetermined period has been developed and evaluated in this study.