A cataract is a leading cause of vision impairment and blindness worldwide, necessitating the search for effective preventive and therapeutic interventions. This study evaluated the methanolic extract of Spirulina platensis family Spirulinaceae for its potential anti-cataract activity using an in vitro goat lens model. Preliminary phytochemical screening of the extract revealed the presence of alkaloids, terpenoids, steroids, tannins, saponins, flavonoids, phenols, coumarins, quinones, and glycosides. The anti-cataract activity of the extract was assessed by inducing cataract formation in goat lenses through exposure to a high-glucose environment. The photographic evaluation demonstrated significant activity at 750μg/ml, significant activity at 500μg/ml, and non-significant activity at 250μg/ml of the extract. Additionally, protein estimation data revealed a dose-dependent increase in protein levels with the extract, suggesting its potential to minimize protein utilization during cataract formation. Furthermore, the extract exhibited dose-dependent increases in the levels of superoxide dismutase (SOD) and glutathione (GSH), important biomarkers involved in counteracting oxidative stress. This indicates the extract's ability to mitigate oxidative stress and potentially slow down the progression of cataracts. Overall, these findings highlight the promising anti-cataract potential of Spirulina platensis methanolic extract.