This review article aims to explore the crucial role of nurses in promoting oral health among pediatric patients undergoing radiation therapy. Radiation therapy is a common treatment for pediatric cancers, but it often leads to various oral health complications such as mucositis, xerostomia, and dental caries. Nurses play a vital role in preventing and managing these complications through education, assessment, and intervention. The review will discuss the impact of radiation therapy on oral health in pediatric patients, the role of nurses in oral health promotion, and evidence-based strategies for preventing and managing oral complications. By highlighting the significance of nursing interventions in oral health care, this review seeks to enhance the quality of life and treatment outcomes for pediatric patients undergoing radiation therapy. This review article will provide valuable insights into the role of nurses in promoting oral health in pediatric patients undergoing radiation therapy. By emphasizing the importance of oral care interventions by nurses, this study aims to improve the overall well-being and treatment experiences of pediatric cancer patients receiving radiation therapy.