Humans are exposed to several chemicals through daily use of different products like food supplements, cosmetics, pharmaceuticals, pesticides, etc. Occupational exposure to chemicals is one of the major routes in which workers of different industries and factories are dreadfully affected. Benzene is such a widely used chemical often required as raw material in the manufacturing of different products like detergents, insecticides, dyes, lubricants, etc. It is a common environmental toxin that is ubiquitously present in the air, water, and soil. This review focuses on general chemical exposure with a specific focus on the potent benzene metabolite parabenzoquinone (p-BQ).The results of this study show that exposure to chemicals from numerous sources poses a major hazard to human health, resulting in a variety of pathophysiological problems. Benzene causes toxicity in various organs by producing reactive intermediates, the most potent of which being p-BQ. The toxicity generated by the benzene metabolite, p-BQ, in several organs sheds more light on the aetiology of cell and tissue damage.