A well-known blue - green algae Spirulina platensis is widely used in India for the management of different ailments. This study aims at extraction, purification and antiangiogenic screening of C-Phycocyanin isolated from Spirulina platensis. Preliminary analysis was performed for Spirulina platensis. Then, it was treated for the extraction of C-Phycocyanin by different extraction procedures, purified and finally characterization was achieved by reverse phase HPLC and by Mass Spectrometry.