The present study endeavours practically for the formulation of ketoprofen-loaded nanosuspension. A central composite design was used for the influence of the formulation variables on the responses. ANOVA was applied to evaluate statistical significance (p<0.05). the prepared nanosuspension was optimized and subsequently lyophilized to obtain the dry nanosuspension. The dry powder of nanosuspension was further analysed using DSC and PXRD. The drug particles were transformed during the processing of the nanosuspension and found to be in amorphous form. The compatibility was studied by the FTIR. The in vitro evaluation was performed and 98 % sustained release was found up to 24 h. In conclusion, CCD is employed to find the effect of variables on their response to the nano formulation. Thus, nanosuspension is the best nano formulation that improves solubility and bioavailability respectively. Thus, the KTP-loaded nanosuspension improves its solubility and bioavailability. Thus, the prepared nanosuspension is cost-effective and safe to improve solubility and bioavailability.