Persistent can evulgarisis characterized by the buildup of dead skin cells and oil in the hair follicles. Acne acne scars ,and uneven skin to near patients with impaired immune systems who reside in warm, humid climates. Many different illnesses can be brought on by them. As a result, novel dosage formulations are being developed to limit disease-causing microorganisms. The Salicylic acid with natural agent (Momordica charantia)-loaded gel was characterized using FTIR. When compared to acetate buffer (pH 5.5) and phosphate buffer (pH 9.0), salicylic acid-loaded gels demonstrated high release. The high concentration allowed for high drug permeability across the Franz diffusion cell. As a gelling agent, carbopol-934 was included in the formulation. Acne treatment is more likely to reach the colony of pimples that has formed because of improved diffusion, the gel produced with carbopol-934 had a high zone of inhibition of10.1±0.1mm and 8.7±0.7. As a result, a salicylic acid-loaded gel with a designed formulation has the potential to cure acne vulgaris as well as other skin illnesses.