Utilising Minitab software, the current work attempted to maximise the circumstances for the creation and production of a Nanosponge-loaded hydrogel for a model Lincosamide antibiotic. Methodology: Factorial design was used to optimise the drug:polymer ratio and surfactant concentration. A two component, three level full factorial design was created and carried out in a fully randomised sequence to examine all potential combinations of both factors at all levels. By varying the drug polymer ratio (1:0.05, 1:0.1, and 1:0.15), nanosponges were made using the emulsion solvent diffusion method, and process variables were optimised using a 32 complete factorial central design