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ISSN 2063-5346
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Fabrication of a Novel Biodegradable Ligands of Paclitaxel Loaded Nanoparticle’s for Targeted Drug Delivery of Specially Breast Cancer Cells

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Sonu Sharma, Shivanee Vyas, Abhishek Banke, Girish Chandra Tiwari, Vipin Sharma, Hitesh Vishwanath Shahare, Yogesh B Zambare, Amandeep Kaur
» doi: 10.48047/ecb/2023.12.si4.1190

Abstract

In recent years, the number of cancer cases has reached an all-time high. Therefore, it is important to promote advanced healing methods that can effectively stop the spread of harmful growths and precancers. These operations should demonstrate the ability to manage cancer and test the viability of conventional remedial professionals. Anticancer medications, such as Paclitaxel (PTX), are indispensable for the treatment of various cancers. Nevertheless, the poor penetrability, rapid efflux from cells, or low water solubility of the majority of medicines severely restrict their usage. Due to their reduced poisonousness, aided drug release, atomic targeting, and additional restorative and imaging capabilities, nanoparticles have frequently been investigated to facilitate medication delivery. Scattering polymerization was used to produce the nanoparticles. Each medication in the mixture made up a fraction of the free drug's centralization. For the two cell types, it was observed that the cytotoxic effects of the drug combination were comparable for the drug-loaded nanoparticle and the free drug structure. Without affecting Paclitaxel's capacity to restore function, the portion was reduced.

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