Background: Non-compliance can be defined as a discontinuation or failure of proper medication intake without prior approval from the treating physician In a review article that summarized findings of studies from 1961 to 1975 and commented that failures of patients to compliance with the treatment is major problem. Some of the main barriers to patient compliance with pharmacological therapy the barriers to medication adherence included four concepts, namely, lifestyle challenges, patient incompatibility, forgetting of medicine use, and no expert advice. These concepts are always present in the disease process and reduce the patients' efforts to achieve normal living and adhere to the medication. Medication non-adherence when patients don’t take their medications as prescribed is unfortunately fairly common, especially among patients with chronic disease. Most non-adherence is intentional patients make a rational decision not to take their medicine based on their knowledge, experience and beliefs There are many reasons for non-compliance with in patients for medication. Aim of the study: To assessment Factor effected for drug-noncompliance in patients attending outpatient clinics in hospitals at Saudi Arabia 2022. Method: Across sectional descriptive study conducted among including Sample population consists of Saudi out patients aged 20-60 years attending to outpatient in selected hospitals in Saudi Arabia, during the October to December, 2022, the Sample size of medical practitioners. Our total participants were (234). Results: Show age majority of the study groups were in the age range of (40-60) years were (43.59%). gender many of the respondents were male (66.24%), the education status, the majority of the respondents had Secondary degree were (32.05%) while had University education were (25.21%), ranged Less than 3000SR bar month were (23.93%) will the participants who are (6000-9000) were (20.94%), regarding the occupation the majority of them working were(61.97) Conclusion: Non-compliance is quite common in patients. Medical practitioners need to be aware of it and address this problem because compliance is directly related to the prognosis of the illness, recommendations to facilitate compliance with were described, which included implementation of effective management practices and allocation of adequate healthcare resources required to facilitate such compliance.