Background: Liver transplantation is a complex and life-saving procedure for patients with end-stage liver diseases. Nurses play a critical role in the care and management of these patients throughout the transplantation process and postoperative recovery. The aim of this study was to evaluate factors affecting nurses’ performance regarding care of patients with liver transplantation. Research design: Descriptive design. Setting: The study was conducted in liver transplant unit in new surgical at Zagazig University Hospital. Subjects: Convenient sample of all available nurses that are 50 bedside nurses. The tool of data collection : Two tools were used for data collection. Tool (I): Interviewing questionnaire for demographic characteristics, nurses’ knowledge, attitude of the studied nurses and factors related to nurses. Tool (II): observational checklist. Results: Factors affecting nursing care of liver transplant patients (56%) positive level, (44%) negative level. Also, 62% of the studied nurses’ social factors affect their care of patients with liver transplantation with mean± SD 18.42±6.07 and range from7 to 27, presence of experienced people in the field affect performance at a higher rate (58%), family and people point of view of nurses during night shift affect their performance at the lowest rate (34%). Conclusion: Total factors (physiological, psychological, social, professional, patient, work environment and relationships inside the workplace) affecting nurses’ performance regarding care of liver transplant patients was more than half positive level. Recommendations: Conducting continuous in-service training advanced through programs for nurses working with patient in critical care units for improving their performance provided to the patients post-LT.