Fixed Dose Combination (FDC) therapy, the simultaneous administration of two or more active pharmaceutical ingredients in a single dosage form, has emerged as a valuable approach in modern medicine. This review article provides a comprehensive assessment of FDC therapy, covering its advantages, challenges, regulatory considerations, and impact on patients and healthcare systems. The review highlights the potential benefits of FDC therapy, including improved treatment outcomes, enhanced medication adherence, simplified dosing regimens, and cost-effectiveness. It also addresses concerns related to safety, efficacy, drug interactions, and regulatory frameworks associated with FDC therapy. By examining relevant literature, clinical studies, and real-world examples, this review aims to enhance the understanding of FDC therapy and its implications for healthcare professionals, regulators, and patients.