Niosome is one of the synthetic nanoparticles which often used as drug delivery system for various applications. The aim of this study was to prepare niosomes encapsulated with ECN and characterized for various physico chemical parameters. Niosomes encapsulated with ECN were prepared by thin-film hydration technique, and encapsulation efficiency was evaluated. Niosome surface morphology and encapsulation efficiency was evaluated. The results show that ECN were successfully loaded in the formulations with encapsulation efficiencies of 79.25% to 91.88% respectively. The zeta potential of ECN encapsulated niosomes were in the range of - 14.5- -30.2 respectively. Niosomes had spherical shapes with rough surfaces. Niosomes were evaluated for invitro drug release studies, in first hour of diffusion studies the drug release was observed ranging from 10.31% to 12.86% for all the formulations and by 12 hrs it was found to be in the range of 78.98% to 94.05%. In conclusion, these ECN encapsulated niosomes have high potential for therapeutic applications.