The purpose of this study was to create ranitidine mucoadhesive microspheres to block H2 receptors. To speed up the start of action, boost medication bioavailability, and get around the notoriously difficult-to-cross bloodbrain barrier, a number of formulations were created utilising spruce gum polymer in drug:polymer ratios ranging from 1:1 to 1:4. Drug loading, entrapment efficiency, histopathological features, in vitro drug release, mucoadhesion in vitro, particle size, manufacturing yield, and swelling property were all measured for the generated mucoadhesive microspheres. Differential scanning calorimetry, scanning electron microscopy, and X-ray diffraction analysis were used to characterise the microspheres after they were created. The manufactured microspheres were perfectly spherical and had a high swelling capacity and a smooth exterior. When mucoadhesive microspheres formulations reach the mucosa, they come into touch with the fluid (containing cations), which causes spontaneous viscous gelation (reducing the clearance rate) in the cavity and increases the residence time, hence increasing the activity by several-folds. This research paved the way for new strategies to improve the therapeutic effectiveness of ranitidine.