The aim of this study was to develop lornoxicam microspheres to overcome its low solubility and subsequently improve its bioavailability. The microspheres were prepared using the solvent evaporation method. Two polymers, Eudragit and Ethyl cellulose, were utilized in different ratios with the drug. In formulation F1, a ratio of 1:3 of drug to Ethyl cellulose was used, while in F2 and F3, the ratios of drug to both polymers were 1:2:1 and 2:5:2, respectively. The formulations underwent evaluation for particle size analysis, drug content, and dissolution rate. The results showed that as the concentration of the polymers increased, the drug encapsulation in the microspheres also increased. Among the formulations, F3 exhibited the best performance. Thus, this study highlights the efficacy of solid dispersion in enhancing the solubility and dissolution rate of poorly soluble drugs like lornoxicam