The objective of the study is to formulate and evaluate pulsatile drug delivery containing a combination of allopurinol and quercetin for the treatment of gouty arthritis which is used to deliver the drug at a specified time by the disease's pathophysiological requirements, improving therapeutic effectiveness and patient compliance. Allopurinol was prepared as a core tablet with varying concentrations of superdisintegrants, microcrystalline cellulose, magnesium stearate, and talc, and as an outer shell tablet with quercetin which is formulated with different weight ratios of ethyl cellulose (EC) and different grades of polyox. The methodology calls for the creation of solid dispersion, pulsatile release tablets, and analytical method development to simultaneously estimate combination medications. An oral press-coated tablet was designed via direct compression to create the time-controlled tablet with a distinct specified lag period. Evaluation studies were performed for prepared pulsatile tablets like thickness, hardness, weight variation, friability, and disintegration time. In in vitro release profile of 8 hours study in the first 6 hours, it shows minimum drug release and at the end of eight hours rapid and transient release was observed.