The purpose of this study was to formulate and evaluate bilayer tablets of immediate release Enalapril maleate for hypertension and sustained release of Glibenclamide for diabetes. Direct compression method was used to formulate bilayer tablets, which contained hydrophilic HPMC K- 100 and hydrophobic Ethyl cellulose as a sustained release polymer and super disintegrating agent such as Croscarmellose sodium in different proportion from batch F1-F6. Formulation of Bilayer tablets was prepared by the FEM1-FEM6 and FG1-FG6 powder blend for different parameters of formulated bilayer tablets were hardness, friability, thickness, drug content, weight variation, and the in-vitro drug release rate pattern results indicated that the formulation F3 was high as compared to other formulations. In formulation F3, percentage drug release of Glibenclamide sustained release layer was 99.98% at 12 hrs. and 98.91% at 90 min for Enalapril Maleate Immediate release layer.